Every process in our body is mediated by highly orchestrated cellular cross-talk. We are interested in understanding how the cellular dialog is established, maintained, and altered by stress. Our research program is bridging rigorous genomic studies of the bone marrow niche with clinical outcomes to devise rational and targeted therapies via the following three directions:


Stress-mediated Bone Marrow Niche remodeling
Leukemic Niche
In and Out of the Bone


Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.

Van Laethem, F., A. N. Tikhonova, L. A. Pobezinsky, X. Tai, M. Y. Kimura, C. Le Saout, T. I. Guinter, A. Adams, S. O. Sharrow, G. Bernhardt, L. Feigenbaum and A. Singer

CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance

Pitt, L. A.*, A. N. Tikhonova*, H. Hu, T. Trimarchi, B. King, Y. Gong, M. Sanchez-Martin, A. Tsirigos, D. R. Littman, A. A. Ferrando, S. J. Morrison, D. R. Fooksman, I. Aifantis and S. R. Schwab

The bone marrow microenvironment at single-cell resolution

Tikhonova, A. N.*#, I. Dolgalev*, H. Hu, K. K. Sivaraj, E. Hoxha, A. Cuesta-Dominguez, S. Pinho, I. Akhmetzyanova, J. Gao, M. Witkowski, M. Guillamot, M. C. Gutkin, Y. Zhang, C. Marier, C. Diefenbach, S. Kousteni, A. Heguy, H. Zhong, D. R. Fooksman, J. M. Butler, A. Economides, P. S. Frenette, R. H. Adams, R. Satija, A. Tsirigos# and I. Aifantis#


Ximing joined our lab as a Ph.D. student

Mursal got accepted to Medical Biophysics Ph.D. Program

We received funding through the Gilead Research Scholars program in Hematology/ Oncology