Every process in our body is mediated by highly orchestrated cellular cross-talk. We are interested in understanding how the cellular dialog is established, maintained, and altered by stress. Our research program is bridging rigorous genomic studies of the bone marrow niche with clinical outcomes to devise rational and targeted therapies via the following three directions:

RESEARCH

Stress-mediated Bone Marrow Niche remodeling
Leukemic Niche
In and Out of the Bone

LATEST PUBLICATIONS

An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup

Gower M, Li X, Aguilar-Navarro AG, Lin B, Fernandez M, Edun G, Nader M, Rondeau V, Arruda A, Tierens A, Eames Seffernick A, Pölönen P, Durocher J, Wagenblast E, Yang L, Lee HS, Mullighan CG, Teachey D, Rashkovan M, Tremblay CS, Herranz D, Itkin T, Loghavi S, Dick JE, Schwartz G, Perusini MA, Sibai H, Hitzler J, Gruber TA, Minden M, Jones CL, Dolgalev I, Jahangiri S, Tikhonova AN. An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup

Under the surface: scratching the ALL niche

Mark Gower and Anastasia Tikhonova

Treatment response in AML—clues in the biopsy core

Alicia G. Aguilar Navarro and Anastasia N. Tikhonova

LATEST NEWS

Mark’s Paper is out!

Thank you TFRI for funding our work!

Congrats to Mark on receiving 2024 IMM-COPRA Grant