Every process in our body is mediated by highly orchestrated cellular cross-talk. We are interested in understanding how the cellular dialog is established, maintained, and altered by stress. Our research program is bridging rigorous genomic studies of the bone marrow niche with clinical outcomes to devise rational and targeted therapies via the following three directions:


Stress-mediated Bone Marrow Niche remodeling
Leukemic Niche
In and Out of the Bone


Stem cells pack some chillis for the road

Anastasia N. Tikhonova & Iannis Aifantis

There won’T be blood

Mark Gower, Gena Foster & Anastasia N. Tikhonova

Connecting the Dots: Resolving the Bone Marrow Niche Heterogeneity

Igor Dolgalev and Anastasia N. Tikhonova


We received NSERC Discovery Grant!

The lab receives CIHR Project Grant funding.