Every process in our body is mediated by highly orchestrated cellular cross-talk. We are interested in understanding how the cellular dialog is established, maintained, and altered by stress. Our research program is bridging rigorous genomic studies of the bone marrow niche with clinical outcomes to devise rational and targeted therapies via the following three directions:


Stress-mediated Bone Marrow Niche remodeling
Leukemic Niche
In and Out of the Bone


Under the surface: scratching the ALL niche

Mark Gower and Anastasia Tikhonova

Treatment response in AML—clues in the biopsy core

Alicia G. Aguilar Navarro and Anastasia N. Tikhonova

Avoiding fratricide: a T-ALL order

Mark Gower, Anastasia N. Tikhonova


Congrats to Mark on receiving 2024 IMM-COPRA Grant

Thank you New Frontiers in Research Fund for funding our work! Collaboration with Dr. Gregory Schwartz https://schwartzlab.ca/